CALCIUM IONOPHORE A23187
4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-[[3,9,11-trimethyl-8-[1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-, [6S-[6α(2S*,3S*),8β(R*),9β,11α]]-
CAS: 52665-69-7
Molecular Formula: C29H37N3O6
CALCIUM IONOPHORE A23187 - Names and Identifiers
| Name | 4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-[[3,9,11-trimethyl-8-[1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-, [6S-[6α (2S*,3S*),8β (R*),9β ,11α ]]- |
| Synonyms | A23187 CALCIMYCIN CALCIMYCIN A23187 IONOPHORE A-23187 A23187 (CalciMycin) CALCIUM IONOPHORE III CALCIUM IONOPHORE A23187 5-(Methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid Bis[5-methylamino-2-[[(6S)-3β,9α,11β-trimethyl-8α-[(S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2β-yl]methyl]-4-benzoxazolecarboxylic acid]calcium salt |
| CAS | 52665-69-7 |
| EINECS | 2580841 |
| InChI | InChI=1/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1 |
CALCIUM IONOPHORE A23187 - Physico-chemical Properties
| Molecular Formula | C29H37N3O6 |
| Molar Mass | 523.62 |
| Density | 1.28±0.1 g/cm3(Predicted) |
| Melting Point | 187-190°C |
| Boling Point | 710.3±55.0 °C(Predicted) |
| Specific Rotation(α) | D25 -56° (c = 1 in chloroform) |
| Flash Point | 383.391°C |
| Solubility | Soluble in DMSO with warming or sonication. Also soluble in ethanol or ethyl acetate |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| Color | white to light yellow |
| Merck | 13,1639 |
| BRN | 1096801 |
| pKa | pKa1 6.9 in 90% DMSO |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 4 months. |
| Refractive Index | 1.611 |
| In vitro study | Calcimycin (A-23187) mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. |
| In vivo study | Calcimycin (A-23187) (2.5 or 7.5 nM; intrapleurally) induces protein leakage. Animal Model: Mice (ICR, 25-30 g) Dosage: 2.5 or 7.5 nM Administration: Intrapleurally Result: Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values. |
CALCIUM IONOPHORE A23187 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | DM4676000 |
| FLUKA BRAND F CODES | 8 |
| HS Code | 29349990 |
| Toxicity | LD50 i.p. in mice: 10 mg/kg (Gale) |
CALCIUM IONOPHORE A23187 - Introduction
An ionophore is a substance consisting of a mixture of calcium and magnesium salts, commonly used as a catalyst and solid electrolyte. The following is an introduction to the nature, use, preparation and safety information of ionophores:
Nature:
1. The calcium magnesium salt mixture has good ionic conductivity and can be used as a solid electrolyte for the preparation of high-performance ion conductive materials.
2. The ion carrier has high thermal stability and chemical stability, and can maintain stability under high temperature or chemical corrosion conditions.
3. The shape and particle size of the ionophore can be adjusted according to specific needs to meet the requirements of different application scenarios.
Use:
1. Catalyst: As a catalyst, the ion carrier can be used in the catalytic reaction process to provide higher reaction activity and selectivity.
2. Solid Electrolyte: ion carrier can be used as electrolyte material for the preparation of solid oxide fuel cells, solid oxide electrolysis cells, etc.
Preparation Method:
The preparation method of the ionophore can be selected according to specific compounds and needs. Common preparation methods include solid-phase reaction, solution impregnation method, mechanical mixing method, etc.
Safety Information:
1. When operating the ionophore, it is necessary to follow the safety procedures, such as wearing protective glasses, gloves and laboratory coats.
2. Avoid contact with skin or inhalation of its dust to avoid discomfort or irritation.
3. Storage, should be sealed, away from combustibles and acid and alkali substances, to avoid accidents.
Nature:
1. The calcium magnesium salt mixture has good ionic conductivity and can be used as a solid electrolyte for the preparation of high-performance ion conductive materials.
2. The ion carrier has high thermal stability and chemical stability, and can maintain stability under high temperature or chemical corrosion conditions.
3. The shape and particle size of the ionophore can be adjusted according to specific needs to meet the requirements of different application scenarios.
Use:
1. Catalyst: As a catalyst, the ion carrier can be used in the catalytic reaction process to provide higher reaction activity and selectivity.
2. Solid Electrolyte: ion carrier can be used as electrolyte material for the preparation of solid oxide fuel cells, solid oxide electrolysis cells, etc.
Preparation Method:
The preparation method of the ionophore can be selected according to specific compounds and needs. Common preparation methods include solid-phase reaction, solution impregnation method, mechanical mixing method, etc.
Safety Information:
1. When operating the ionophore, it is necessary to follow the safety procedures, such as wearing protective glasses, gloves and laboratory coats.
2. Avoid contact with skin or inhalation of its dust to avoid discomfort or irritation.
3. Storage, should be sealed, away from combustibles and acid and alkali substances, to avoid accidents.
Last Update：2024-04-09 01:59:53
